Abstract
Purpose: To assess the efficacy and safety of intravitreal conbercept injections in patients with macular edema (ME) secondary to branch retinal vein occlusion (BRVO).
Methods: The study included 33 patients (38 eyes) with ME secondary to BRVO who received intravitreal conbercept 0.05mL injections. The ophthalmological examination should be performed at least once a month during 6-month follow up, and central foveal thickness was measured with optical coherence tomography (OCT) to determine whether reinjection was needed. We compared the best corrected visual acuity (BCVA) between pretreatment and 1, 3 months after treatment, aslo the OCT results between pretreatment and 1 month after treatment. Moreover, we observed the occurrence of complications within 1 month after treatment.
Results: The logarithm of minimum visual acuity (VA) was 0.59 ± 0.21 at baseline, and improved to 0.35 ±0.12 after the first injection (P<0.01). The BCVA was statistically different between baseline and 1, 3 months after treatment (P＜0.05), and the BCVA at 3 months after treatment was significantly higher than baseline (P<0.05). The central foveal thickness was also statistically different between baseline and 1 month after treatment (P<0.05). Only 5 patients (15.15%) had transient elevation of intraocular pressure, and no other obvious ocular adverse events were observed within 1 month after treatment.
Conclusion:Intravitreal injections of conbercept demonstrated a generally favorable short-term efficacy as well as safety in the treatment of ME due to BRVO based on OCT.

Keywords
Conbercept; Branch retinal vein occlusion ; Macular edema ; Optical coherence tomography.

Cite this paper
Kai Xing, Zefeng Kang, Efficacy of Intravitreal Conbercept Injections in Macular Edema Secondary to Branch Retinal vein Occlusion , SCIREA Journal of Clinical Medicine. Volume 5, Issue 1, February 2020 | PP. 1-7.

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